Effect of late-onset on multiple sclerosis phenotype and outcome: evidence from a multi-national registry - PubMed
3 months ago
- #Disease Progression
- #Multiple Sclerosis
- #Aging
- Study examines the impact of late-onset (LOMS) and very late-onset (vLOMS) multiple sclerosis (MS) on disease severity and disability outcomes compared to adult-onset MS (AOMS).
- Data from the MSBase registry categorized patients into AOMS (18-39 years), transition onset (40-49 years), LOMS (50-59 years), and vLOMS (≥60 years).
- Primary progressive MS was more common in LOMS (21.7%) and vLOMS (24%) patients.
- LOMS and vLOMS patients showed significantly higher risks of disability progression, reaching EDSS milestones (4 and 6), conversion to secondary progressive MS (SPMS), and progression independent of relapse activity (PIRA).
- Hazard ratios (HR) indicated increased risks for LOMS and vLOMS patients across all measured outcomes, with vLOMS showing the highest risk for severe disability (EDSS 6 HR=6.33).
- Conclusion: Late-onset MS is associated with more progressive disease onset and worse disability outcomes compared to adult-onset MS.