Degradation of G-quadruplex-binding proteins in chromatin using G4-ligand-based proteolysis-targeting chimeras - PubMed
7 hours ago
- #cancer
- #PROTACs
- #G-quadruplex
- Targeted protein degradation approach for G-quadruplex (G4)-binding proteins in chromatin.
- Uses G4-ligand-based proteolysis-targeting chimeras (PROTACs) to degrade G4-specific proteins.
- G4 structures are abundant in cancer and associated with transcriptionally active genes.
- Degrades key proteins like FUS, SMARCA4, and ATRX, involved in transcription and DNA repair.
- Potential therapeutic strategy for diseases with aberrant G4 activity, such as cancers.