MafB is a conserved transcriptional regulator of macrophage development and functional identity across tissues and species - PubMed
5 hours ago
- #MafB
- #transcriptional regulation
- #macrophage
- MafB is a conserved transcriptional regulator essential for macrophage development and functional identity across tissues and species.
- MafB deficiency disrupts resident tissue macrophage (RTM) development, retaining them in an immature CD52high stage and impairing functions like phagocytosis and tissue-specific roles.
- MafB directly regulates key RTM genes (e.g., Csf1r, Mertk, Fcgr1, Cd163, Zeb2) in both mice and humans, with evolutionary conservation of its binding sites.
- The study links MafB-dependent transcriptional programs to defining features of RTMs and their role in tissue homeostasis.