A heteromeric TRP channel that functions as a WNT-activated G protein-coupled receptor - PubMed
7 hours ago
- #polycystic kidney disease
- #TRP channel
- #GPCR
- PKD1, an 11-transmembrane protein with a noncanonical TRP channel architecture, functions as a GPCR.
- PKD1 acts as a WNT-activated receptor, coupling to Gαi1-3 subunits to inhibit cAMP accumulation.
- PKD2 chaperones PKD1 to the plasma membrane, enabling its GPCR function.
- Mutations in PKD1 or PKD2 are linked to autosomal dominant polycystic kidney disease (ADPKD).
- The study provides insights into ADPKD pathogenesis and potential therapeutic targets.