Diagnostic accuracy of the Gold Coast Criteria for amyotrophic lateral sclerosis: a systematic review and meta-analysis - PubMed
4 hours ago
- #Meta-Analysis
- #Amyotrophic Lateral Sclerosis
- #Diagnostic Accuracy
- The study compares the diagnostic accuracy of the Gold Coast Criteria (GCC) with Revised El Escorial Criteria (rEEC) and Awaji Criteria (AC) for amyotrophic lateral sclerosis (ALS).
- GCC shows higher sensitivity (over 95%) but lower specificity (66%) than rEEC and AC, making it better for early recognition but requiring caution in low-prevalence settings.
- GCC achieved the highest area under the curve (AUC) of 0.95 and diagnostic odds ratio of 36.1, indicating superior overall diagnostic performance.
- The findings are based on a meta-analysis of nine studies from ALS referral centers, but applicability in general neurology populations remains uncertain.