Concordance analysis of DNA and RNA profiling: The MD Anderson IMPACT2 study in precision oncology - PubMed
4 hours ago
- #cancer treatment
- #DNA RNA profiling
- #precision oncology
- The study explores the concordance between DNA and RNA profiling in cancer treatment selection.
- DNA profiling is established for cancer treatment, while RNA profiling is investigational.
- IMPACT2 study involved 829 patients, with RNA profiling performed on 253 patients.
- Findings show significant associations between DNA and RNA alterations, including TP53 and VEGFA.
- Patients with ≥6 genes with altered expression had shorter overall survival (6.7 months).
- TP53 alterations with VEGFA overexpression may explain tumor response to bevacizumab.
- Multiple authors report extensive research support and consulting roles in oncology.