Ocimum tenuiflorum L. extracts attenuate polycystic ovarian syndrome in letrozole treated female Wistar rats through modulation of iNOS, COX-2, IL-1β and TNF-α - PubMed
8 hours ago
- #Herbal Medicine
- #PCOS Treatment
- #Anti-inflammatory
- Study investigated the effect of Ocimum tenuiflorum extracts (methanol and ethyl acetate) on letrozole-induced polycystic ovarian syndrome (PCOS) in female Wistar rats.
- Extracts showed significant in vitro anti-inflammatory activity, inhibiting protein denaturation, proteinase activity, erythrocyte membrane hemolysis, and nitric oxide activity at 600 μg/mL concentration.
- In vivo treatment with extracts reduced serum testosterone and estradiol levels, decreased ovarian follicular cysts, and down-regulated inflammatory genes (iNOS, COX-2, TNF-α, IL-1β) in PCOS-induced rats.
- GC-MS analysis identified active compounds responsible for the anti-inflammatory effects, supporting the therapeutic potential of Ocimum tenuiflorum for PCOS through hormonal regulation and anti-inflammatory mechanisms.
- Research concluded that Ocimum tenuiflorum extracts attenuate PCOS symptoms by restoring hormonal balance and modulating inflammatory pathways, with no toxic effects observed in rats.