Neurovascular dysfunction in the development and progression of neuroinflammatory diseases - PubMed
5 hours ago
- #blood-brain barrier
- #neurovascular unit
- #neurodegenerative diseases
- The neurovascular unit (NVU) maintains the blood-brain barrier and regulates cerebral blood flow, crucial for brain homeostasis.
- Disruption of the NVU is a key feature in neurodegenerative diseases, leading to BBB breakdown, neuroinflammation, and neuronal dysfunction.
- Specific disease mechanisms include immune-driven inflammation in MS, protease activity in stroke, and protein-related damage in PD, AD, and ALS.
- The review focuses on immune-mediated BBB disruption and its role in disease progression across common neurodegenerative conditions.