Unveiling the Roles of PRDX6 and SLC6A9 in Intracerebral Hemorrhage-Associated White Matter Lesions - PubMed
5 hours ago
- #Intracerebral hemorrhage
- #White matter lesions
- #Genetic research
- Intracerebral hemorrhage (ICH) often leads to white matter lesions (WML), causing persistent neurological deficits.
- PRDX6 was identified as a high-risk gene, and SLC6A9 as a potential low-risk gene for WML following ICH.
- PRDX6 may be involved in antioxidant defense and metabolic processes, while SLC6A9 may be associated with transmembrane transport and neuroprotective functions.
- The study used Mendelian randomization and single-cell RNA sequencing to explore genetic contributors to WML post-ICH.
- Findings provide insights into the pathophysiology of ICH-induced WML and suggest potential therapeutic targets.