Liver Resection for Non-Colorectal Liver Metastases: The Good, the Bad and the Ugly - PubMed
6 hours ago
- #Noncolorectal cancer
- #Liver metastases
- #Hepatectomy
- Liver resection (LR) for non-colorectal liver metastases (NONCOLMET) shows varied survival outcomes depending on the primary tumor type.
- Best outcomes are seen in neuroendocrine tumors (median OS 84-120 months) and GIST responding to tyrosine kinase inhibitors (median OS 70-90 months).
- Breast and selected uro-gynecological cancers show median OS above 36 months, while esophageal, gastric, and pancreatic cancers benefit only in highly selected cases.
- Favorable prognostic factors include oligometastatic/liver-only disease, longer disease-free interval, and response to systemic therapy (e.g., CA19-9 decline, ER/PR positivity, HER2/PD-L1 expression).
- Comparative analyses suggest survival benefit from LR in biologically favorable subsets of NONCOLMET patients.
- Multidisciplinary evaluation and tumor-specific selection criteria are crucial for optimal outcomes.