Upper Extremity Deep Vein Thrombosis in Cancer Patients: Clinical Course by Cancer Site - PubMed

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Upper extremity deep vein thrombosis (UEDVT) is common in cancer patients, with limited data on recurrence and bleeding risks.
The study analyzed 5,195 UEDVT patients from the RIETE registry, including 2,210 with cancer, over 24 months.
Cancer patients had higher cumulative incidences of recurrent VTE (3.9% vs. 2.5%) and bleeding (6.8% vs. 4.3%) compared to non-cancer patients.
Recurrence rates varied by cancer site: highest in lung cancer (6.4%), followed by gastrointestinal (4.0%), genitourinary (3.6%), breast (2.5%), and hematologic (1.4%).
During anticoagulation, lung cancer and younger age were associated with recurrence, while genitourinary cancer and transient risk factors were linked to bleeding.
After anticoagulation discontinuation, longer anticoagulation durations (91-180 days and >180 days) were associated with lower recurrence compared to 30 days or less.
Cancer-associated UEDVT carries higher risks than noncancer UEDVT, with lung cancer having the highest recurrence during treatment and extended anticoagulation reducing post-treatment recurrence.

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