Peripheral Cannabinoid Receptor Activation Attenuates Frostbite-Induced Chronic Pain via Modulation of TRP Channels, Neuroinflammation, and Autophagy - PubMed
3 days ago
- #Frostbite Pain
- #Cannabinoid Receptor
- #TRP Channels
- Frostbite injury leads to persistent chronic pain even after tissue healing.
- Peripheral cannabinoid receptor activation with CB13 attenuates frostbite-induced chronic pain.
- CB13 dose-dependently reduces mechanical and cold allodynia without central nervous system side effects.
- Frostbite increases expression of TRPV1, TRPA1, TRPV4, and TRPM8 channels and pro-inflammatory cytokines.
- CB13 treatment reverses pathological changes, restores autophagy signaling, and reduces oxidative stress.
- Peripheral cannabinoid agonists like CB13 are promising for treating chronic pain from cold injuries.