The changing epidemiology of human type 2 diabetes-associated atherosclerosis: Pathophysiological mechanisms and emerging treatment possibilities - PubMed
4 hours ago
- #cardiovascular complications
- #atherosclerosis
- #type 2 diabetes
- Type 2 diabetes (T2D) is strongly linked to atherosclerosis and macrovascular complications, which are leading causes of death in T2D patients.
- Despite a decline in cardiovascular events, T2D patients still have about double the risk compared to non-diabetics.
- Current therapies focus on lipid metabolism or inflammation, but recent human plaque studies show no differences in lipid or inflammatory marker levels in T2D plaques, possibly due to improved treatments.
- T2D plaques may have distinct features like thin fibrous caps and large necrotic cores, and T2D can affect processes such as oxidative stress and efferocytosis.
- The review highlights the need for targeted therapies specific to T2D-associated atherosclerosis, focusing on shifting epidemiology and biological changes to guide future clinical approaches.