AI-enabled single-cell dissection of the palmitoylation landscape identifies a multicellular prognostic program in gastric cancer - PubMed
4 days ago
- #single-cell RNA sequencing
- #gastric cancer
- #palmitoylation
- AI-enabled single-cell dissection identifies palmitoylation-linked states in gastric cancer.
- Palmitoylation-high malignant program predicts worse survival with increased fatty-acid metabolism and Ras-MAPK signaling.
- Spatial mapping reveals co-localized niches of palmitoylation-high tumor cells interacting with immunosuppressive myeloid cells and CAF subsets.
- An 87-gene multicellular palmitoylation signature derived for risk stratification, associated with adverse outcomes.
- Drug-response modeling highlights vulnerabilities involving the HSP90-PI3K/MAPK axis.
- SH3BGRL identified as a key driver within the poor-prognosis program through functional assays and xenografts.