Di-(2-ethylhexyl) terephthalate promotes breast cancer progression: Multi-omics integrated experimental validation - PubMed
5 hours ago
- #breast cancer
- #multi-omics
- #carcinogenic risk
- Di-(2-ethylhexyl) terephthalate (DOTP) is an alternative plasticizer used in food packaging and medical devices.
- The study assesses DOTP's systemic carcinogenic risk using multi-omics approaches like gene enrichment, machine learning, and molecular docking.
- 24 core carcinogenic genes of DOTP were identified using 11 topological algorithms.
- Six high-affinity carcinogenic targets for DOTP were identified: PIK3CA, PTPN11, ESR1, PPARG, PTGS2, and MAPK1.
- DOTP exposure promotes tumor cell proliferation in a concentration-dependent manner.
- DOTP may interfere with cell proliferation, gene transcription, tumor microenvironment, and carcinogenic signaling pathways like PI3K-Akt-mTOR.
- The study provides insights into DOTP's role in tumor development and environmental pollutant carcinogenesis.