Voxel-mirrored homotopic connectivity in upper motor neuron-dominant amyotrophic lateral sclerosis is associated with different spread directions - PubMed
5 hours ago
- #VMHC
- #ALS
- #Functional Connectivity
- Voxel-mirrored homotopic connectivity (VMHC) measures synchrony of neural activities between symmetrical brain regions, mediated by the corpus callosum.
- Study compares homotopic functional connectivity (FC) in upper motor neuron-dominant ALS (UMN-D ALS) patients with horizontal (group H) and vertical (group V) symptom spread directions.
- Group H showed greater VMHC values in the superior frontal gyrus (SFG) compared to group V and healthy controls, indicating increased homotopic FC possibly due to early bilateral limb involvement and compensatory mechanisms.
- Differences in VMHC values between spread directions suggest a relationship between brain function and symptom evolution in ALS.
- The study contributes to understanding how structural and functional brain changes correlate with symptom spread in UMN-D ALS.