A single mutation in nonstructural protein 1 is critical for the adaptive evolution of influenza B virus - PubMed
5 hours ago
- #mitophagy
- #NS1 protein
- #Influenza B virus
- A single mutation in the nonstructural protein 1 (NS1) of influenza B virus (IBV) is crucial for its adaptive evolution.
- Recent IBV strains show enhanced ability to evade innate immune responses and increased replication efficiency compared to earlier strains.
- NS1 of recent IBV strains interacts with TUFM and LC3B to induce mitophagy, leading to MAVS degradation and suppression of interferon production.
- Earlier IBV strains' NS1 has minimal ability to trigger mitophagy-mediated MAVS degradation.
- Over the past two decades, IBV acquired a phenylalanine (F)-to-leucine (L) substitution at residue 247 of NS1, altering its interaction with LC3B.
- A recent IBV strain with the NS1-L247F mutation shows diminished NS1-LC3B binding, impaired mitophagy, and attenuated replication.
- The study demonstrates that adaptive evolution via a single NS1 mutation enables mitophagy-mediated innate immune evasion, aiding IBV host adaptation.