Medial prefrontal cortex-targeted low-intensity focused ultrasound alleviates migraine-related allodynia and affective symptoms via modulating glutamate/GABA balance in mice - PubMed
3 hours ago
- #neuromodulation
- #migraine
- #neurobiology
- Low-intensity focused ultrasound (LIFU) targeted at the medial prefrontal cortex (mPFC) reduces migraine-related pain and anxiety in mice.
- LIFU modulates glutamate and GABA balance in the mPFC, reversing excitatory-inhibitory imbalance caused by migraine induction.
- The treatment is non-invasive and safe, showing no significant histopathological damage or apoptosis.
- Study suggests LIFU as a novel neuromodulatory strategy for migraine abortive treatment with potential for clinical translation.