Mitochondria transfer in Glioblastoma - PubMed
5 hours ago
- #Mitochondria Transfer
- #Glioblastoma
- #OXPHOS
- Glioblastoma (GBM) is an aggressive brain tumor with high metabolic adaptability and therapy resistance.
- Horizontal mitochondrial transfer (HMT) occurs between GBM cells and their microenvironment, aiding tumor progression and treatment resistance.
- Mitochondrial exchange in GBM happens via tunneling nanotubes (TNTs), tumor microtubes (TMs), and possibly extracellular vesicles (EVs).
- HMT enhances oxidative phosphorylation (OXPHOS), increases tumorigenicity, and alters therapeutic responses.
- Further research is needed to understand the molecular drivers and context-specific outcomes of mitochondrial transfer in GBM for new therapies.