Conserved CD4+ T cell staphylococcal and streptococcal epitopes enable broad-acting vaccines in mice - PubMed
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- #antibiotic resistance
- #vaccine development
- #T cell immunity
- Immunopeptidomics identifies conserved CD4+ T cell epitopes in S. aureus and streptococcal species.
- The Hup epitope is highly conserved and immunodominant, triggering cross-species-reactive CD4+ T cells in mice and humans.
- Vaccination with the Hup epitope induces broad-spectrum protection against S. aureus and S. pneumoniae infections.
- Core gene-derived antigens may enable vaccines against multiple antibiotic-resistant bacterial strains.
- Authors disclose patents and advisory roles related to Hup-based vaccines.