Hyperactivation of sympathetic nerves fuels basophil infiltration in atopic dermatitis - PubMed
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- #basophils
- #sympathetic nervous system
- #atopic dermatitis
- Emotional stress exacerbates atopic dermatitis (AD) and contributes to disease burden.
- Hyperactivation of peripheral sympathetic nervous system (SNS) in affected skin was observed in a murine AD model.
- Disruption of SNS signaling (via denervation or anxiety relief) reduced skin inflammation.
- Basophils are key effector cells regulated by SNS activity via β2-adrenergic receptors.
- Norepinephrine enhances basophil motility and the CCL6-CCR1 chemokine axis, promoting inflammation.
- Human AD lesions show sympathetic nerve remodeling, with basophil-associated CCL23 and CCR1 linked to severity.
- The SNS-basophil axis connects emotional states to skin inflammation, suggesting autonomic regulation as a therapeutic target.