Mitochondrial dysfunction in neurodegenerative disorders: mechanisms and therapeutic advances - PubMed
2 hours ago
- #Therapeutic Advances
- #Neurodegenerative Diseases
- #Mitochondrial Dysfunction
- Mitochondrial dysfunction is a key pathogenic mechanism in neurodegenerative disorders like Alzheimer's and Parkinson's diseases.
- Defects in mitochondrial and nuclear DNA disrupt processes such as oxidative phosphorylation, dynamics, and calcium homeostasis, leading to energy depletion and neuronal degeneration.
- Recent advances include improved diagnostic technologies and therapeutic strategies like metabolic modulators, antioxidants, gene-targeted therapies, and organelle replacement.
- Challenges remain in clinical translation, with future directions focusing on developing mechanism-informed combination therapies.