Choroidal-ventricular system abnormalities are linked to amyloid-β aggregation in Alzheimer's disease - PubMed
6 hours ago
- #Alzheimer's disease
- #choroidal-ventricular system
- #amyloid-beta
- Choroidal-ventricular system abnormalities are linked to amyloid-β (Aβ) aggregation in Alzheimer's disease (AD).
- Enlargement of the choroidal-ventricular system occurs in aging and AD, with emerging evidence connecting these abnormalities to Aβ aggregation.
- The study analyzed ventricular volume, choroid-plexus volume, and ventricular radioactivity in 385 TRIAD and 282 ADNI participants using linear models and partial correlations.
- With advancing AD stages, ventricular and choroid-plexus volumes increased while ventricular radioactivity declined, even in amyloid-negative elderly.
- These measures correlated with amyloid- and tau-PET, CSF and plasma p-tau isoforms, GFAP, and cognition.
- Voxel-wise analyses showed strong associations with cortical Aβ, mediating downstream tau effects.
- Changes in the choroidal-ventricular system are mutually correlated and have an additive effect on cortical Aβ load.