Functional and structural basis of a negative allostery within GABAB hetero-tetramers - PubMed
5 hours ago
- #GPCR
- #GABAB receptor
- #allostery
- GABAB receptor is an obligatory heterodimer and can form stable oligomers.
- GABAB oligomers exist in neurons and their function is affected by human disease-associated mutations.
- Cryo-EM structure of a hetero-tetramer in the apo state shows asymmetrical interaction preventing activation of one unit.
- Negative allosteric interaction between GPCRs is related to human diseases.
- Patent application filed for GABAB nanobodies described in the study.