Skin commensal Cutibacterium acnes alleviates UVB-induced solar dermatitis via ceramide-mediated TLR4-MyD88-NF-κB - PubMed
4 days ago
- #UVB protection
- #Ceramide
- #Cutibacterium acnes
- Cutibacterium acnes (C. acnes) is enriched in healthy high-altitude residents compared to those with plateau solar dermatitis (PSD).
- Topical application of C. acnes reduces UVB-induced skin inflammation, collagen degradation, and DNA damage in mice.
- Multi-omics analyses identify bacterial-derived ceramides (CER2 and CER14) as key protective metabolites against UVB damage.
- Ceramides from C. acnes suppress TLR4-MyD88-NF-κB signaling, reducing UVB-induced apoptosis, oxidative stress, and DNA damage in keratinocytes.
- The study highlights the photoprotective role of skin microbiota and suggests microbiome-based strategies for UVB protection.