Clostridia from preterm infants metabolize human milk oligosaccharides to suppress pathobionts and modulate intestinal function in organoids - PubMed
5 hours ago
- #preterm-infants
- #Clostridia
- #HMOs
- Clostridia from preterm infants metabolize human milk oligosaccharides (HMOs).
- Clostridium perfringens (lacking toxin PfoA) metabolizes HMOs, producing beneficial metabolites like short-chain fatty acids and tryptophan catabolites.
- Metabolites from C. perfringens promote growth of commensal bifidobacteria and inhibit pathobionts in preterm infant gut.
- Cell-free supernatant from C. perfringens suppresses inflammation in preterm-derived intestinal organoids.
- Findings suggest pfoA- C. perfringens strains may contribute to healthy infant gut development.