Mucosal vaccination in mice provides protection from diverse respiratory threats - PubMed
4 days ago
- #respiratory protection
- #universal vaccine
- #mucosal vaccination
- Mucosal vaccination in mice using a liposomal formulation with TLR4 and 7/8 ligands provides broad protection against diverse respiratory threats.
- The vaccine demonstrated durable protection for at least 3 months against pathogens like SARS-CoV-2, Staphylococcus aureus, and other viruses, bacteria, and allergens.
- Protection is mediated by persistent ovalbumin-specific CD4+ and CD8+ memory T cells that enhance alveolar macrophage antigen presentation and antiviral immunity.
- Vaccinated mice showed rapid pathogen-specific T cell and antibody responses, along with ectopic lymphoid structure formation in the lungs.
- The findings suggest a potential for 'universal vaccines' against a wide range of respiratory threats.