Maternal cytokine profile and anti-bacterial specific antibody response associated with neonatal infection by E. coli and K. pneumoniae - PubMed
4 hours ago
- #neonatal infection
- #maternal cytokines
- #antibody response
- Maternal transmission of E. coli and K. pneumoniae contributes to neonatal morbidity/mortality in low/middle-income countries.
- Mothers with positive bacterial cultures and their newborns had higher plasma IL-6, IL-8, and TNF-α levels versus healthy controls.
- Similar cytokine elevations (IL-6, TNF-α) occurred in leukocytes stimulated with TLR4 and TLR1/2 ligands.
- Mothers of infected newborns showed higher IL-6 but lower specific IgG anti-LPS antibodies against the bacteria.
- ROC analysis linked maternal IL-6 and specific IgG levels to perinatal bacterial transmission risk.
- Elevated IL-6 and reduced anti-bacterial IgG in pregnant women with positive cultures indicate increased transmission risk.