A Single-Cell Transcriptomic Atlas Elucidates a Microglial Gene Signature Linking Ferroptosis to Mitochondrial Dysfunction in Epilepsy - PubMed
6 hours ago
- #microglia
- #ferroptosis
- #epilepsy
- The study integrates snRNA-seq and bulk RNA-seq data to explore cell-specific roles in epilepsy, focusing on ferroptosis and mitochondrial dysfunction.
- Six key microglial genes (ATM, TGFBR1, ZEB1, PARP14, GJA1, ALOX5) are identified, linking ferroptosis and mitochondrial dysfunction in epilepsy.
- Analyses reveal associations with immune infiltration, such as increased Th1 cells and reduced CD8+ T cells, and enrichment in neuroinflammatory pathways and interferon response.
- PARP14 is upregulated in epileptic rats and identified as a novel factor in epileptogenesis, while GJA1 shows stable binding with bleomycin, suggesting therapeutic potential.
- In vivo validation confirms ferroptosis and mitochondrial damage in epilepsy, highlighting these processes as targets for future mechanistic and therapeutic research.