Development and Internal Validation of a Pretransplant Biomarker Panel for Mortality Prediction Following Liver Transplant - PubMed
3 months ago
- #mortality prediction
- #biomarkers
- #liver transplant
- Development of a pretransplant biomarker panel (Liver Immune Frailty Index - LIFI) to predict post-liver transplant (LT) mortality.
- Identified key biomarkers (fractalkine and MMP3) associated with 1-year post-LT mortality.
- LIFI stratifies patients into low, moderate, and high risk with 1-year mortality rates of 1.9%, 10.3%, and 63.6% respectively.
- LIFI demonstrated strong discrimination (C statistic, 0.83) and was linked to post-LT infections, longer hospital stays, and reduced survival.
- Offers a preoperative tool to refine transplant candidacy and improve outcomes.