Molecular mechanisms of metformin action: From metabolic effects to lifespan extension and healthspan promotion - PubMed
5 hours ago
- #metformin
- #longevity
- #anti-ageing
- Metformin, primarily used for type 2 diabetes, shows potential anti-ageing effects.
- Mechanisms include AMPK activation, mTOR inhibition, reduced oxidative stress, and modulation of mitochondrial biogenesis.
- Animal studies indicate metformin extends lifespan and healthspan.
- Human epidemiological data suggest reduced risks of cancer, cardiovascular disease, and cognitive decline in metformin users.
- The TAME trial is assessing metformin's effects on ageing in non-diabetic populations.
- Uncertainties remain about optimal dosing, long-term safety, and effectiveness in healthy ageing populations.
- Metformin's multi-targeted actions and safety profile make it a candidate for anti-ageing therapy.
- Further clinical validation is needed to confirm and implement these findings.