A model of coagulation-related genes for prediction of prognosis in lung adenocarcinoma and verification in vitro - PubMed
5 days ago
- #LUAD
- #prognostic model
- #coagulation
- Study focuses on identifying coagulation-related biomarkers for lung adenocarcinoma (LUAD) prognosis.
- A predictive model (CRRS) was developed using Cox and lasso analyses from TCGA-LUAD and Genecards databases.
- The model's accuracy was validated through Kaplan-Meier, ROC curves, and external validation.
- CRRS is an independent prognostic factor and correlates with clinical indicators and immune checkpoint expression.
- ASPH expression was validated via IHC and its downregulation impairs LUAD cell malignancy.
- The CRRS model offers reliable prognostic value, with ASPH as a potential biomarker and therapeutic target.