Antibiotic and Nonantibiotic Drugs Associated With Clostridioides difficile Infection Risk: a Pharmacopoeia-Wide Case-Cohort Study - PubMed
5 hours ago
- #Microbiome
- #Antibiotic-associated diarrhea
- #Clostridioides difficile
- Study examines antibiotic and nonantibiotic drugs associated with Clostridioides difficile infection (CDI) risk in elderly residents.
- Case-cohort study design with logistic regression analysis on 16,196 CDI cases and 549,831 controls.
- Top antibiotics increasing CDI risk: clindamycin (OR 16.83), amoxicillin-clavulanate (OR 6.05), ciprofloxacin (OR 3.83), cephalexin (OR 3.05).
- Nonantibiotic drugs like pantoprazole (OR 1.33) and ferrous fumarate (OR 1.71) also elevate CDI risk.
- Metformin shows a protective effect against CDI (OR 0.67).
- In vitro anticommensal activity of drugs positively correlates with CDI risk (P < .001).
- Findings suggest avenues for CDI stewardship and drug repurposing to combat antimicrobial resistance.