ACSL4-mediated astrocyte ferroptosis augments neuroinflammation and exacerbates NMOSD pathology - PubMed
4 hours ago
- #NMOSD
- #ACSL4
- #astrocyte ferroptosis
- ACSL4-mediated astrocyte ferroptosis contributes to NMOSD pathology.
- Single-nucleus RNA sequencing identified astrocytic ferroptosis in NMOSD mouse models.
- In vitro NMOSD models showed increased Fe²⁺ levels, lipid peroxidation, and reduced glutathione.
- Inflammatory reactive astrocytes were significantly increased in NMOSD pathology.
- ACSL4 upregulation in astrocytes was validated in NMOSD models and reversed by Egr1 siRNA.
- Suppressing ACSL4 mitigated astrocytic ferroptosis, reduced reactive astrocytes, and improved NMOSD prognosis.
- Targeting ACSL4 may be a promising therapeutic strategy for NMOSD.