A targeting lentiviral vector for generation of CAR-T cells in vivo - PubMed
5 hours ago
- #In Vivo Engineering
- #CAR-T
- #Lentiviral Vector
- Development of a T cell-specific lentiviral vector for in vivo CAR-T cell generation.
- The lentiviral vector uses an engineered Sindbis virus envelope to target human T cells specifically, without affecting other immune cells.
- No additional anti-CD3/CD28 stimulation is required for primary T cell activation during in vitro infection.
- Successful delivery of a CD19-targeting CAR molecule to human primary T cells in vivo.
- In vivo generated CD19-CAR-T cells effectively cleared B cell lymphoma.
- Potential to simplify CAR-T cell therapy by eliminating the need for ex vivo T cell engineering.