CD14 plays a critical role in pain and inflammation across multiple models of post-traumatic osteoarthritis - PubMed
6 hours ago
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- #inflammation
- #osteoarthritis
- CD14 plays a critical role in pain and inflammation in post-traumatic osteoarthritis (PTOA).
- Increased sCD14 in human synovial fluid correlates with joint effusion and knee hyperalgesia.
- Targeting CD14 protects against pain behaviors and mobility impairments in murine PTOA models.
- CD14-deficiency modulates synovial and fat pad inflammation, reducing myeloid populations and affecting fibroblasts.
- Local delivery of a CD14 blocking antibody alleviates OA-associated pain and mobility loss across models.
- Blockade of CD14 can safely reduce OA pain and disability post-injury.