TNF-α/PAD4 axis drives hyperhomocysteine-induced white matter injury after acute ischemic stroke - PubMed
5 hours ago
- #ischemic stroke
- #white matter repair
- #hyperhomocysteine
- Hyperhomocysteine (HHcy) worsens stroke prognosis by impairing oligodendrocyte precursor cells (OPCs) differentiation.
- HHcy upregulates TNF-α, leading to PAD4 nuclear translocation and nucleosomal citrullinated histone 3 (CitH3) upregulation.
- This process downregulates myelin regulatory factor (MyRF), inhibiting OPC differentiation and white matter (WM) repair.
- Pharmacological inhibition of PAD4 with YW3-56 promotes OPC differentiation and enhances WM repair post-stroke.
- The TNF-α/PAD4 pathway is identified as a novel therapeutic target for improving neurological outcomes after stroke.