Apolipoprotein C3 exacerbates vascular calcification by promoting ferroptosis via the TLR2/AMPK pathway in vascular smooth muscle cells - PubMed
6 hours ago
- #Vascular Calcification
- #Ferroptosis
- #Chronic Kidney Disease
- Apolipoprotein C3 (ApoC3) exacerbates vascular calcification (VC) by promoting ferroptosis via the TLR2/AMPK pathway in vascular smooth muscle cells (VSMCs).
- ApoC3 levels are positively correlated with VC in patients with chronic renal failure (CRF).
- ApoC3 overexpression increases calcium deposition and ferroptosis in calcified aortas and VSMCs, while ApoC3 deficiency alleviates these effects.
- ApoC3 inhibits the AMPK/NRF2 signaling pathway via TLR2, downregulates SLC7A11 and GPX4, increases lipid peroxidation, and promotes ferroptosis.
- Knockdown of ApoC3 by siRNA attenuates calcification in human renal arterial rings.
- ApoC3 may be a potential therapeutic target for VC treatment.