Sleep deprivation exacerbates hepatic steatosis by promoting hepatic inflammation and oxidative stress through gut microbiota dysbiosis in metabolic dysfunction-associated fatty liver disease rat - Pu
5 hours ago
- #MASLD
- #Sleep deprivation
- #Gut microbiota
- Sleep deprivation worsens hepatic steatosis in metabolic dysfunction-associated fatty liver disease (MASLD) rats.
- The study used forced exercise to create sleep deprivation models in Sprague-Dawley rats over 8 weeks.
- Sleep deprivation led to more severe metabolic disorders, liver injury, and increased pro-inflammatory cytokines and oxidative stress.
- Gut microbiota dysbiosis was identified as a key factor in MASLD development, worsened by sleep deprivation.
- Fecal microbiota transplantation (FMT) showed potential in restoring gut microbiota balance and improving liver conditions.
- The findings suggest targeting gut microbiota could be a therapeutic strategy for MASLD and sleep-related disorders.