Autologous platelet-rich plasma versus hyaluronic acid, corticosteroids or saline for knee osteoarthritis: can blood draw volume serve as a proxy for platelet dose? A systematic review and meta-analys
5 hours ago
- #Meta-analysis
- #Knee osteoarthritis
- #Platelet-rich plasma
- PRP shows superior pain and function outcomes compared to HA, CS, and NS at six months, with benefits lasting up to twelve months against HA and CS.
- Blood draw volume ≥40 mL in PRP vs HA trials correlates with better six-month WOMAC and twelve-month VAS improvements.
- The study includes 62 trials with 4,969 participants, highlighting substantial heterogeneity and varying evidence certainty.
- Blood draw volume may serve as a proxy for platelet dose when the latter is unreported.
- Authors disclose potential competing interests due to affiliations with organizations providing PRP treatments.