Native chromatome profiling reveals hundreds of metabolic enzymes in the nucleus across tissues - PubMed
5 days ago
- #chromatome profiling
- #nuclear metabolism
- #metabolic enzymes
- Native chromatome profiling identifies hundreds of metabolic enzymes in the nucleus across various tissues.
- Metabolic and epigenetic rewiring are key features of cancer, with potential crosstalk between these processes.
- The study reveals widespread chromatin association of metabolic enzymes across different tissues and metabolic pathways.
- The abundance of metabolic enzymes on chromatin is tissue-specific, with oxidative phosphorylation proteins notably depleted in lung cancer.
- One-carbon folate enzymes dynamically associate with chromatin and are involved in DNA damage and repair processes.
- Restricting metabolic enzymes to specific subcellular compartments can rewire the transcriptome, indicating non-canonical nuclear roles.
- The findings suggest new insights into the functional relationship between metabolism and chromatin regulation.
- The study highlights the nucleus as a hub for metabolic enzymes, impacting chromatin function and cancer progression.