Type 2 lymphocytes restrict type 3 lymphocytes during liver fibrosis and colocalize in fibroblast niches - PubMed
14 hours ago
- #fibroblast niches
- #lymphocytes
- #liver fibrosis
- Type 2 lymphocytes (T2Ls) and type 3/17 lymphocytes (T3Ls) interact with fibroblasts to influence tissue repair and fibrosis.
- IL-13 from T2Ls and IL-17A from T3Ls are linked to inflammation and fibrosis, with their spatial positioning affecting organ remodeling.
- In liver injury models, T2Ls (mainly ILC2s) were found near T3Ls and fibroblasts, adjacent to profibrotic myofibroblasts.
- Ablation of T2Ls worsened liver fibrosis and increased IL-17A+ T3Ls (γδ T cells), while concurrent ablation of T2Ls and T3Ls reduced fibrosis.
- The study suggests a spatially associated cross-talk between lymphocytes and fibroblast niches that can lead to pathological fibrosis.