An in vivo fitness gene of Toxoplasma, MIC11, is essential for PLP1-mediated egress from host cells - PubMed
6 hours ago
- #Host cell egress
- #Toxoplasma gondii
- #MIC11
- Identifies MIC11 as a key in vivo fitness gene for Toxoplasma gondii, essential for host cell egress.
- MIC11 deletion causes severe defects in membrane rupture and egress, linked to PLP1-mediated permeabilization.
- Scanning mutagenesis reveals functional motifs in MIC11, supporting its association with PLP1 in membrane disruption.
- MIC22, a merozoite-specific paralogue, can functionally complement MIC11 deletion, indicating conserved egress mechanisms in feline stages.