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Dapagliflozin alleviates renal fibrosis in type 2 diabetic mice through regulating STAT3 - PubMed

4 hours ago
  • #STAT3
  • #Renal Fibrosis
  • #Dapagliflozin
  • Dapagliflozin, a sodium-glucose co-transporter 2 inhibitor, shows therapeutic efficacy in type 2 diabetes.
  • The study explores dapagliflozin's effects on renal fibrosis in diabetic mice and renal tubular epithelial cells under hyperglycemic conditions.
  • Dapagliflozin treatment reduces fibrosis biomarkers like Matrix Metallopeptidase 2, Transforming Growth Factors 1, phosphorylated Smad2/3, collagen III, and α-smooth muscle actin.
  • The antifibrotic effect is linked to dapagliflozin's inhibition of STAT3 phosphorylation and nuclear migration.
  • STAT3 knockdown experiments confirm its role in reducing renal fibrosis markers.
  • The study highlights dapagliflozin's potential in mitigating diabetes-induced kidney fibrosis by targeting STAT3 activation.