Role of Disulfidptosis in the Local Inflammatory Response of Atopic Dermatitis - PubMed
6 hours ago
- #inflammation
- #disulfidptosis
- #atopic-dermatitis
- Disulfidptosis, a novel form of programmed cell death, is investigated for its role in atopic dermatitis (AD) pathogenesis.
- RNA-seq analysis identified 4,239, 3,570, and 516 differentially expressed genes (DEGs) between lesional skin (LS), non-lesional skin (NL), and healthy controls (HC).
- Four disulfidptosis-related genes (ACTB, GYS1, SLC7A11, MYH9) were upregulated in LS and associated with AD via WGCNA.
- HDM-treated HaCaT cells exhibited disulfidptotic features, including F-actin collapse and redox imbalance (elevated NADP+/NADPH ratio).
- HDM exposure triggered pro-inflammatory cytokine upregulation (IL-25, IL-33, TSLP, IL-6, IL-8), linking disulfidptosis to AD inflammation.