Dynamic collaboration between mitochondria and organelles: mechanisms, functions, and disease implications - PubMed
5 hours ago
- #Mitochondria
- #Disease Mechanisms
- #Organelle Interactions
- Dysregulation of mitochondria-organelle interactions contributes to pathological processes and infections.
- In Alzheimer's disease, dysfunctional MAMs cause calcium overload and oxidative stress.
- Cancer cells remodel mitochondria-Golgi interactions to enhance glycolysis.
- Targeting key interacting nodes shows therapeutic potential for diseases like cancer and neurodegenerative disorders.
- Spatiotemporal dynamics and tissue specificity of organelle interactions in diseases remain unclear.
- Understanding collaborative networks offers new treatment targets and insights into pathogen-host mechanisms.