ACAT1-mediated lactylation reprogramming governs immune-stromal crosstalk in ulcerative colitis - PubMed
5 hours ago
- #Ulcerative Colitis
- #Immune Microenvironment
- #Lactylation
- ACAT1 is identified as a key lactylation-associated hub gene in ulcerative colitis (UC) through machine learning and bioinformatics analyses.
- Lactylation reprogramming, mediated by ACAT1, influences immune-stromal interactions and UC pathogenesis, with ACAT1 downregulation in active UC phases.
- Immune microenvironment profiling reveals myeloid cell heterogeneity and causal immune-UC relationships via Mendelian randomization.
- ACAT1 overexpression reduces lactate accumulation and lactylation in experimental models, suggesting its role as a diagnostic biomarker and therapeutic target.
- Sulfasalazine is identified as a potential ACAT1-directed small molecule through cMAP mining and molecular docking studies.