Supplements and Drugs Are Associated With Biological Age in a Cohort of Exceptionally Healthy Individuals - PubMed

4 hours ago

The study analyzed data from 4,260 'health enthusiasts' who used saliva-based DNA epigenetic tests and completed lifestyle and supplement questionnaires.
A proprietary 9-CpG epigenetic clock with a mean absolute error of 5.4 years was used to measure biological age.
High supplement use (71% prevalence) in the cohort provided power to study supplement effects compared to general population studies.
Delayed-release calcium-alpha-ketoglutarate (dAKG) with vitamins (Rejuvant) was associated with an average 1.8-year lower biological age (Age Residual) in cross-sectional analysis.
Regular AKG use showed a smaller, statistically insignificant benefit compared to dAKG supplement.
Among medications, antihistamine use had a non-significant benefit, limited by sample size.
In a longitudinal subset, coenzyme Q10 (CoQ10) and dAKG intake were associated with increased odds of lower biological age, but results were not significant after multivariate correction.
The study highlights the utility of saliva-based epigenetic tests for aging research and identifies AKG and CoQ10 as promising supplements for further investigation.
Limitations include healthy user and recruitment bias, requiring future controlled trials to address.

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