The vicious cycle: unraveling the interplay between α-synuclein, mitochondrial dysfunction, and neuroinflammation in Parkinson's disease - PubMed
4 hours ago
- #Parkinson's disease
- #Neuroinflammation
- #α-synuclein
- Parkinson's disease (PD) is the second most common neurodegenerative disorder, marked by motor and non-motor symptoms.
- The pathogenesis involves a complex interplay between genetic and environmental factors.
- Abnormal aggregation of α-synuclein, mitochondrial dysfunction, and neuroinflammation are core drivers of PD.
- These components interact in a networked manner, contributing to disease progression.
- The review explores their independent mechanisms and regulatory interactions.
- It summarizes therapeutic targets and synergistic strategies for disease-modifying therapy and early intervention.