Paraquat induces neuroinflammation through glycolysis reprogramming in microglia: evidence from network toxicology analysis and in vitro experiments - PubMed
6 hours ago
- #microglia
- #neuroinflammation
- #glycolysis
- Paraquat (PQ) is linked to Parkinson's disease, but the mechanisms are not fully understood.
- Network toxicology analysis predicted PQ targets microglia, causing glucose metabolism disorder.
- PQ enhances glycolysis in BV2 cells, increasing lactate, HK2, GLUT-1 expression, and glycolysis flux.
- PQ activates mTOR and inhibits AMPK, promoting pro-inflammatory polarization in microglia.
- Inhibiting glycolysis or silencing HK2 reduces PQ-induced inflammation and dopaminergic neuron apoptosis.
- Microglial glycolysis reprogramming is a key mechanism in PQ neurotoxicity and neuroinflammation.
- Targeting microglial glycolysis could be a potential intervention for neurodegenerative disorders.